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The typical silymarin dosage used in most studies was ~420 mg/day divided into 2 or 3 doses. Generic Name : Silymarin Pronunciation : SILL-ee-MAR-inn Latest prescription information about Silymarin. The silymarin exerts membrane-stabilizing and antioxidant activity, it promotes hepatocyte regeneration; furthermore it reduces the inflammatory reaction, and inhibits the fibrogenesis in the liver. Side Effects & Safety When taken by mouth: N-acetyl cysteine is LIKELY SAFE for most adults. The IV median lethal dose in rodents was suggested to be around 4 g/kg. The four-year survival rate was 58 percent in the silymarin group and 39 percent in the placebo group. Silymarin promotes liver cell protein synthesis and decreases the oxidation of glutathione. Search drug, interactions and image information in China, Hong Kong, Taiwan, Malaysia, Singapore, Philippines, Vietnam, Thailand, Indonesia, India & USA Silymarin is a fruit extract from the plant milk thistle that is claimed to be a free radical scavenger and to have hepatoprotectant properties; it has been used in various liver … In people with liver disease, the typical dosage was higher, around 1.3 g/day of the standardized for 6 – 8 weeks (divided into 3 doses during the day). The reduced death rate among those taking silymarin was most pronounced in the alcoholic cirrhosis subgroup. A 30-day study in rats found no toxicity at 150 mg/kg/day. References. The recommended dose is 140 mg 2-3 timesday. 70mg-capsule: 2 capsule/time x 3 times a day. It can cause nausea, vomiting, and diarrhea or constipation. Brief stomach upset and mild allergies, but no serious side effects, have been reported. Common side effects of Silymarin : Abdominal bloating, diarrhea, flatulence, loss of appetite, nausea and stomach upset. There were no side effects from silymarin.4 It may be unsafe for your child. How should Silymarin be used: It comes as a tablet, capsule, and syrup to take by mouth, with food. The dosage has not been established in pediatric patients. What is the dose of Legalon® (Silymarin) for an adult? 140 Tablet:Role of Silymarin- Powerful antioxidant; Used to protect liver cells (and other cells in the body and brain) from toxins. 140mg-capsule: 1 capsule/time x 3 times a day. What is the dose of Legalon® (Silymarin) for a child? Subjects received 140 mg silymarin three times a day for 41 months. Beneficial in a number of diseases involving liver disease; Direction for use/Dosage: – Take as directed by the physician 1. Phytosome technology improves the bioavailability of silybin as it is complexed with phosphatidylcholine. Silymarin may intensify the effects of drugs that decrease blood sugar levels (hypoglycemic drugs). Click here for full details on all the markets covered. Schauss AG, Somfai-Relle S, Financsek I, et al. MIMS products are highly valued and utilised widely across Australia by healthcare professionals in public and private acute care, primary care, aged care, community services – just to name a few. The combination of silybin and phosphatidylcholine in Liverprime is three times better absorbed than plain Silymarin. These results have been established by experimental and clinical trials. In dogs given oral citicoline 1.5 g/kg daily for 6 months, no biochemical, neurological, or histological toxicity was found.1. Silymarin ) for a child details on all the markets covered diarrhea constipation... As a tablet, capsule, and diarrhea or constipation and 39 percent in placebo! 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